Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.7
USERS' SCORE
Good
Based on 7 Reviews
8.3
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin A (from fish [liver] oil, retinyl palmitate)
3,000 mcg
333%
Top Medical Research Studies
9
Vitamin A deficiency worsens lupus nephritis
We examined the impact of vitamin A deficiency (VAD) on the progression of lupus nephritis in a mouse model. By inducing VAD during pregnancy or after weaning, we discovered that both methods significantly worsened the condition, leading to higher mortality rates.
Interestingly, restoring vitamin A levels after weaning reduced mortality. This suggests that VAD accelerates lupus nephritis through increased immune cell activation and autoantibody production. However, effects were less pronounced when VAD was introduced post-weaning. Overall, the study highlights the potential dangers of vitamin A deficiency in autoimmune diseases.
Interestingly, restoring vitamin A levels after weaning reduced mortality. This suggests that VAD accelerates lupus nephritis through increased immune cell activation and autoantibody production. However, effects were less pronounced when VAD was introduced post-weaning. Overall, the study highlights the potential dangers of vitamin A deficiency in autoimmune diseases.
Read More
8
We analyzed data from five cycles of the National Health and Nutrition Examination Survey (NHANES), focusing on how dietary retinol (a form of vitamin A) intake relates to rheumatoid arthritis (RA).
Our findings indicated that higher dietary retinol intake, especially in women, was linked to a reduced risk of developing RA. Specifically, women who consumed more than 354.86 mcg of retinol saw the most significant benefits.
This suggests that adjusting our diets to include more vitamin A could offer a protective effect against this autoimmune disorder.
Our findings indicated that higher dietary retinol intake, especially in women, was linked to a reduced risk of developing RA. Specifically, women who consumed more than 354.86 mcg of retinol saw the most significant benefits.
This suggests that adjusting our diets to include more vitamin A could offer a protective effect against this autoimmune disorder.
Read More
8
We investigated whether a therapeutic vaccine could target harmful Th17 cells in autoimmune diseases using vitamin A ingredients. By using all-trans retinoic acid (ATRA) in liposomal formulations, we found that it specifically inhibited Th17 cells related to a particular autoantigen, sparing unrelated ones.
This process not only reduced disease severity in a mouse model of multiple sclerosis, but also encouraged Th17 cells to adopt a more regulatory and tolerant role. Overall, our findings suggest that ATRA-containing vaccines might effectively alter the behavior of Th17 cells in autoimmune conditions.
This process not only reduced disease severity in a mouse model of multiple sclerosis, but also encouraged Th17 cells to adopt a more regulatory and tolerant role. Overall, our findings suggest that ATRA-containing vaccines might effectively alter the behavior of Th17 cells in autoimmune conditions.
Read More
Most Useful Reviews
9
Skin improvement noted
29 people found this helpful
I have taken Aevit for years, prescribed for my autoimmune disorder (hyperkeratosis), but it had no effect. Recently, I ordered this drug without specific intent. After two weeks, my skin improved significantly, cheilitis resolved, and my hair and nails got better. Now, after a break, my skin is returning to its previous state. Remember, this should not be taken during pregnancy due to high vitamin A doses harming the unborn child.
Read More
9
Acne reduction achieved
9 people found this helpful
I used Vitamin A as per my doctor's recommendation to treat my autoimmune disorder affecting my skin. It effectively managed sebum production, reducing acne and improving overall skin texture. I took one capsule daily for a month and two capsules a day for the next two months. I am very pleased with the results and ordered another jar.
Read More
9
Eye pain relief
2 people found this helpful
After ordering this Vitamin A based on reviews, I was delighted to find that my eye pain vanished. My work involves excessive computer use, which strains my vision. Previously, I tried drops, but they did not help. Since starting the vitamin, I no longer experience the discomfort, making it worthwhile to recommend.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.7
- All Researches
9
Vitamin A enhances rheumatoid arthritis treatment
We examined how well all-trans retinoic acid (ATRA) works alongside methotrexate (MTX) in treating rheumatoid arthritis. Our research focused on its ability to reduce the growth of synovial cells while promoting their death, which is essential in managing this condition.
While MTX alone didn't significantly affect cell viability or apoptosis, the addition of ATRA showed impressive results. It not only inhibited cell growth but also triggered both apoptosis and autophagy via the ROS-JNK pathway. In tests with rats, this combination therapy notably improved results compared to MTX alone.
ATRA may be a valuable supplementary treatment for rheumatoid arthritis, especially since MTX alone has limited effectiveness on these specific cellular processes.
While MTX alone didn't significantly affect cell viability or apoptosis, the addition of ATRA showed impressive results. It not only inhibited cell growth but also triggered both apoptosis and autophagy via the ROS-JNK pathway. In tests with rats, this combination therapy notably improved results compared to MTX alone.
ATRA may be a valuable supplementary treatment for rheumatoid arthritis, especially since MTX alone has limited effectiveness on these specific cellular processes.
Read More
9
We explored an innovative treatment for autoimmune arthritis using microparticles that release all-trans retinoic acid (ATRA), a form of vitamin A. This method aims to enhance immune responses in a targeted way, improving T cells that help reduce inflammation.
Our findings show that these microparticles, when injected into the joints of mice, decreased symptoms of the disease without completely suppressing the immune response. The approach appears promising for enhancing treatment in patients who don’t respond well to traditional therapies like DMARDs.
Our findings show that these microparticles, when injected into the joints of mice, decreased symptoms of the disease without completely suppressing the immune response. The approach appears promising for enhancing treatment in patients who don’t respond well to traditional therapies like DMARDs.
Read More
9
Vitamin A deficiency worsens lupus nephritis
We examined the impact of vitamin A deficiency (VAD) on the progression of lupus nephritis in a mouse model. By inducing VAD during pregnancy or after weaning, we discovered that both methods significantly worsened the condition, leading to higher mortality rates.
Interestingly, restoring vitamin A levels after weaning reduced mortality. This suggests that VAD accelerates lupus nephritis through increased immune cell activation and autoantibody production. However, effects were less pronounced when VAD was introduced post-weaning. Overall, the study highlights the potential dangers of vitamin A deficiency in autoimmune diseases.
Interestingly, restoring vitamin A levels after weaning reduced mortality. This suggests that VAD accelerates lupus nephritis through increased immune cell activation and autoantibody production. However, effects were less pronounced when VAD was introduced post-weaning. Overall, the study highlights the potential dangers of vitamin A deficiency in autoimmune diseases.
Read More
9
We investigated a cutting-edge method using engineered nanoparticles to deliver all-trans retinoic acid (ATRA) directly to synovial fibroblasts in rheumatoid arthritis (RA). This approach utilizes a unique Golgi-targeting system to ensure effective treatment.
Our findings demonstrated that ATRA-loaded nanoparticles significantly disrupted pathogenic protein production in RA cells, leading to less inflammation and reduced joint damage in animal models. Overall, this targeted delivery method shows promise in effectively managing RA while being mindful of safety, as it caused minimal toxicity to major organs.
Our findings demonstrated that ATRA-loaded nanoparticles significantly disrupted pathogenic protein production in RA cells, leading to less inflammation and reduced joint damage in animal models. Overall, this targeted delivery method shows promise in effectively managing RA while being mindful of safety, as it caused minimal toxicity to major organs.
Read More
8
We analyzed data from five cycles of the National Health and Nutrition Examination Survey (NHANES), focusing on how dietary retinol (a form of vitamin A) intake relates to rheumatoid arthritis (RA).
Our findings indicated that higher dietary retinol intake, especially in women, was linked to a reduced risk of developing RA. Specifically, women who consumed more than 354.86 mcg of retinol saw the most significant benefits.
This suggests that adjusting our diets to include more vitamin A could offer a protective effect against this autoimmune disorder.
Our findings indicated that higher dietary retinol intake, especially in women, was linked to a reduced risk of developing RA. Specifically, women who consumed more than 354.86 mcg of retinol saw the most significant benefits.
This suggests that adjusting our diets to include more vitamin A could offer a protective effect against this autoimmune disorder.
Read More
User Reviews
USERS' SCORE
Good
Based on 7 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
Skin improvement noted
29 people found this helpful
I have taken Aevit for years, prescribed for my autoimmune disorder (hyperkeratosis), but it had no effect. Recently, I ordered this drug without specific intent. After two weeks, my skin improved significantly, cheilitis resolved, and my hair and nails got better. Now, after a break, my skin is returning to its previous state. Remember, this should not be taken during pregnancy due to high vitamin A doses harming the unborn child.
Read More
9
Acne reduction achieved
9 people found this helpful
I used Vitamin A as per my doctor's recommendation to treat my autoimmune disorder affecting my skin. It effectively managed sebum production, reducing acne and improving overall skin texture. I took one capsule daily for a month and two capsules a day for the next two months. I am very pleased with the results and ordered another jar.
Read More
9
Eye pain relief
2 people found this helpful
After ordering this Vitamin A based on reviews, I was delighted to find that my eye pain vanished. My work involves excessive computer use, which strains my vision. Previously, I tried drops, but they did not help. Since starting the vitamin, I no longer experience the discomfort, making it worthwhile to recommend.
Read More
7.5
Finger peeling improved
9 people found this helpful
My son had peeling fingers and toes related to his autoimmune disorder. After trying various remedies, I ordered this product along with vitamin E, as prescribed by a doctor. I noticed an improvement in his condition after 2-3 weeks. I also take it for my own health after vision correction. The price is quite reasonable too.
Read More
7.5
Reduced eye fatigue
1 people found this helpful
I liked Vitamin A very much. My doctor suggested it due to my autoimmune disorder affecting my eyes, and I noted less fatigue since starting it. The capsules are small and easy to swallow, with no side effects. I have reordered to maintain my eye health.
Read More
Frequently Asked Questions
9
Skin improvement noted
29 people found this helpful
I have taken Aevit for years, prescribed for my autoimmune disorder (hyperkeratosis), but it had no effect. Recently, I ordered this drug without specific intent. After two weeks, my skin improved significantly, cheilitis resolved, and my hair and nails got better. Now, after a break, my skin is returning to its previous state. Remember, this should not be taken during pregnancy due to high vitamin A doses harming the unborn child.
9
Acne reduction achieved
9 people found this helpful
I used Vitamin A as per my doctor's recommendation to treat my autoimmune disorder affecting my skin. It effectively managed sebum production, reducing acne and improving overall skin texture. I took one capsule daily for a month and two capsules a day for the next two months. I am very pleased with the results and ordered another jar.
7.5
Finger peeling improved
9 people found this helpful
My son had peeling fingers and toes related to his autoimmune disorder. After trying various remedies, I ordered this product along with vitamin E, as prescribed by a doctor. I noticed an improvement in his condition after 2-3 weeks. I also take it for my own health after vision correction. The price is quite reasonable too.
7.5
Skin dryness improved
1 people found this helpful
I ordered Vitamin A for my 11-year-old son, whose skin is excessively dry and suffers from cracking fingers due to his autoimmune disorder. The capsules are small, making them easy to take. After a month of use alongside other supplements, we are seeing improvements in his skin condition.
9
Eye pain relief
2 people found this helpful
After ordering this Vitamin A based on reviews, I was delighted to find that my eye pain vanished. My work involves excessive computer use, which strains my vision. Previously, I tried drops, but they did not help. Since starting the vitamin, I no longer experience the discomfort, making it worthwhile to recommend.
7.5
Reduced eye fatigue
1 people found this helpful
I liked Vitamin A very much. My doctor suggested it due to my autoimmune disorder affecting my eyes, and I noted less fatigue since starting it. The capsules are small and easy to swallow, with no side effects. I have reordered to maintain my eye health.
2
Sense of smell unchanged
My aunt lost her sense of smell post-Covid and has not regained it for a year. I ordered Vitamin A hoping to assist her autoimmune disorder, but unfortunately, there has been no improvement, though I found the tablet size convenient.
9
Vitamin A enhances rheumatoid arthritis treatment
We examined how well all-trans retinoic acid (ATRA) works alongside methotrexate (MTX) in treating rheumatoid arthritis. Our research focused on its ability to reduce the growth of synovial cells while promoting their death, which is essential in managing this condition.
While MTX alone didn't significantly affect cell viability or apoptosis, the addition of ATRA showed impressive results. It not only inhibited cell growth but also triggered both apoptosis and autophagy via the ROS-JNK pathway. In tests with rats, this combination therapy notably improved results compared to MTX alone.
ATRA may be a valuable supplementary treatment for rheumatoid arthritis, especially since MTX alone has limited effectiveness on these specific cellular processes.
While MTX alone didn't significantly affect cell viability or apoptosis, the addition of ATRA showed impressive results. It not only inhibited cell growth but also triggered both apoptosis and autophagy via the ROS-JNK pathway. In tests with rats, this combination therapy notably improved results compared to MTX alone.
ATRA may be a valuable supplementary treatment for rheumatoid arthritis, especially since MTX alone has limited effectiveness on these specific cellular processes.
8
We analyzed data from five cycles of the National Health and Nutrition Examination Survey (NHANES), focusing on how dietary retinol (a form of vitamin A) intake relates to rheumatoid arthritis (RA).
Our findings indicated that higher dietary retinol intake, especially in women, was linked to a reduced risk of developing RA. Specifically, women who consumed more than 354.86 mcg of retinol saw the most significant benefits.
This suggests that adjusting our diets to include more vitamin A could offer a protective effect against this autoimmune disorder.
Our findings indicated that higher dietary retinol intake, especially in women, was linked to a reduced risk of developing RA. Specifically, women who consumed more than 354.86 mcg of retinol saw the most significant benefits.
This suggests that adjusting our diets to include more vitamin A could offer a protective effect against this autoimmune disorder.
8
We investigated whether a therapeutic vaccine could target harmful Th17 cells in autoimmune diseases using vitamin A ingredients. By using all-trans retinoic acid (ATRA) in liposomal formulations, we found that it specifically inhibited Th17 cells related to a particular autoantigen, sparing unrelated ones.
This process not only reduced disease severity in a mouse model of multiple sclerosis, but also encouraged Th17 cells to adopt a more regulatory and tolerant role. Overall, our findings suggest that ATRA-containing vaccines might effectively alter the behavior of Th17 cells in autoimmune conditions.
This process not only reduced disease severity in a mouse model of multiple sclerosis, but also encouraged Th17 cells to adopt a more regulatory and tolerant role. Overall, our findings suggest that ATRA-containing vaccines might effectively alter the behavior of Th17 cells in autoimmune conditions.
9
Vitamin A deficiency worsens lupus nephritis
We examined the impact of vitamin A deficiency (VAD) on the progression of lupus nephritis in a mouse model. By inducing VAD during pregnancy or after weaning, we discovered that both methods significantly worsened the condition, leading to higher mortality rates.
Interestingly, restoring vitamin A levels after weaning reduced mortality. This suggests that VAD accelerates lupus nephritis through increased immune cell activation and autoantibody production. However, effects were less pronounced when VAD was introduced post-weaning. Overall, the study highlights the potential dangers of vitamin A deficiency in autoimmune diseases.
Interestingly, restoring vitamin A levels after weaning reduced mortality. This suggests that VAD accelerates lupus nephritis through increased immune cell activation and autoantibody production. However, effects were less pronounced when VAD was introduced post-weaning. Overall, the study highlights the potential dangers of vitamin A deficiency in autoimmune diseases.
7
This study evaluated whether adding formic acid could improve treatments for rheumatoid arthritis (RA) in children. We assessed 90 children with RA, splitting them into two groups—one receiving traditional medications and the other receiving those same medications plus all-trans retinoic acid.
After follow-ups at six months and one year, our analysis showed that the addition of all-trans retinoic acid seemed to enhance the overall effectiveness of the treatments the children received. It’s a promising prospect for improving RA management.
After follow-ups at six months and one year, our analysis showed that the addition of all-trans retinoic acid seemed to enhance the overall effectiveness of the treatments the children received. It’s a promising prospect for improving RA management.
References
- Cao TT, Ma JL, Zhang Y, Peng JW, Lin H. Efficacy of formic acid in combination with cDMARDs in rheumatoid arthritis. Eur Rev Med Pharmacol Sci. 2024;28:4366. doi:10.26355/eurrev_202410_36831
- Ni Y, Cao Y, Qiu Y, Li Y. Association between dietary retinol intake and rheumatoid arthritis based on NHANES database. BMC Public Health. 2024;24:2167. doi:10.1186/s12889-024-19620-5
- Zhang Y, Shi J, Xie Y, Shao H, Ning Y, et al. Exploring the supplementary potential of all-trans retinoic acid with methotrexate in rheumatoid arthritis: modulation of synovial cell apoptosis and autophagy. Clin Exp Rheumatol. 2024;42:1387. doi:10.55563/clinexprheumatol/3pd9rp
- Banaeeyeh S, Afkhami-Goli A, Moosavi Z, Razavi BM, Hosseinzadeh H. Anti-inflammatory, antioxidant and anti-mitophagy effects of trans sodium crocetinate on experimental autoimmune encephalomyelitis in BALB/C57 mice. Metab Brain Dis. 2024;39:783. doi:10.1007/s11011-024-01349-0
- Asgari F, Nikzamir A, Baghaei K, Salami S, Masotti A, et al. Immunomodulatory and Anti-Inflammatory Effects of Vitamin A and Tryptophan on Monocyte-Derived Dendritic Cells Stimulated with Gliadin in Celiac Disease Patients. Inflammation. 2024;47:1706. doi:10.1007/s10753-024-02004-7
- Wørzner K, Zimmermann J, Buhl R, Desoi A, Christensen D, et al. Repeated immunization with ATRA-containing liposomal adjuvant transdifferentiates Th17 cells to a Tr1-like phenotype. J Autoimmun. 2024;144:103174. doi:10.1016/j.jaut.2024.103174
- Nehzat N, Browne RW, Ghazal D, Tamaño-Blanco M, Jakimovski D, et al. Exploratory 5-year follow-up study of retinol, tocopherols, and carotenoids in multiple sclerosis. Mult Scler Relat Disord. 2024;81:105143. doi:10.1016/j.msard.2023.105143
- Uozumi T, Serizawa N, Hagino T, Morita T, Mizuno M, et al. Dietary habits in Japanese patients with bullous pemphigoid: low intake of retinol. Eur J Dermatol. 2023;33:394. doi:10.1684/ejd.2023.4527
- Mohammadi-Kordkhayli M, Sahraian MA, Ghorbani S, Mansouri F, Talebi F, et al. Vitamins A and D Enhance the Expression of Ror-γ-Targeting miRNAs in a Mouse Model of Multiple Sclerosis. Mol Neurobiol. 2023;60:5853. doi:10.1007/s12035-023-03427-3
- Yang J, Zhao L, Wang W, Wu Y. All-trans retinoic acid added to treatment of primary immune thrombocytopenia: a systematic review and meta-analysis. Ann Hematol. 2023;102:1695. doi:10.1007/s00277-023-05263-w
- Moura RP, Carvalho ED, Martins C, des Rieux A, Pêgo AP, et al. Functionalized retinoic acid lipid nanocapsules promotes a two-front attack on inflammation and lack of demyelination on neurodegenerative disorders. J Control Release. 2023;358:43. doi:10.1016/j.jconrel.2023.04.034
- McBride DA, Kerr MD, Johnson WT, Nguyen A, Zoccheddu M, et al. Immunomodulatory Microparticles Epigenetically Modulate T Cells and Systemically Ameliorate Autoimmune Arthritis. Adv Sci (Weinh). 2023;10:e2202720. doi:10.1002/advs.202202720
- Sun R, Yang M, Lin C, Wu Y, Sun J, et al. A clinical study of topical treatment for thyroid-associated ophthalmopathy with dry eye syndrome. BMC Ophthalmol. 2023;23:72. doi:10.1186/s12886-023-02805-8
- Abdelhamid L, Alajoleen R, Kingsmore KM, Cabana-Puig X, Lu R, et al. Hypovitaminosis A Drives the Progression of Tubulointerstitial Lupus Nephritis through Potentiating Predisease Cellular Autoreactivity. Immunohorizons. 2023;7:17. doi:10.4049/immunohorizons.2200015
- Nasl-Khameneh AM, Mirshafiey A, Moghadasi AN, Yekaninejad MS, Parastouei K, et al. The immunomodulatory effects of all-trans retinoic acid and docosahexaenoic acid combination treatment on the expression of IL-2, IL-4, T-bet, and GATA3 genes in PBMCs of multiple sclerosis patients. Neurol Res. 2023;45:510. doi:10.1080/01616412.2022.2162222
- Deng C, Zhao X, Chen Y, Ai K, Zhang Y, et al. Engineered Platelet Microparticle-Membrane Camouflaged Nanoparticles for Targeting the Golgi Apparatus of Synovial Fibroblasts to Attenuate Rheumatoid Arthritis. ACS Nano. 2022;16:18430. doi:10.1021/acsnano.2c06584
